Active case-finding to improve tuberculosis control.

Is active case finding necessary to control tuberculosis in developing countries?

Tuberculosis is one of the world’s leading causes of death and disease. Despite effective treatment, tuberculosis still results in several million deaths each year. Reducing the burden of global TB disease is a part the Millennium Development Goals. Earlier, health authorities thought that DOTS (Direct Observed Treatment, Short course) would control tuberculosis. However, we now recognize that DOTS alone is unable of reducing TB incidence in high endemic countries.

Active case finding is to find, diagnose, and treat and follow up tuberculosis patients in the local communities.

To find out the efficacy of community-based case finding, we did a community randomized trial and cost-effectiveness analysis in south Ethiopia. The trial Ethiopia aimed to evaluate if community health workers could improved smear-positive case detection and treatment success rates (Datiko and Lindtjørn, 2009 and Datiko and Lindtjørn, 2010).

The study showed that involving of health extension workers (HEWs) in sputum collection and treatment improved smear-positive case detection and treatment success rate, possibly because of an improved service access. This finding has policy implications and could be applied in settings with low health service coverage and a shortage of health workers.

Recently, National TB Control Programme in Ethiopia started to decentralize case finding and treatment to local communities (in Ethiopia called kebeles) using community based-treatment by health extension workers.

We plan to follow up our earlier studies and develop a model for community DOTS in rural Ethiopia. We aim to improve the community-based implementation of case finding and treatment of TB in rural settings of southern Ethiopia. This will try to develop community-based tuberculosis registries, and registries of patients with symptoms suggestive of tuberculosis.  Through this work we aim to see if case finding and treatment outcomes can be improved on a larger scale and involving larger populations

Datiko, D., & Lindtjørn, B. (2009). Health Extension Workers Improve Tuberculosis Case Detection and Treatment Success in Southern Ethiopia: A Community Randomized Trial PLoS ONE, 4 (5) DOI: 10.1371/journal.pone.0005443

Datiko, D., & Lindtjørn, B. (2010). Cost and Cost-Effectiveness of Treating Smear-Positive Tuberculosis by Health Extension Workers in Ethiopia: An Ancillary Cost-Effectiveness Analysis of Community Randomized Trial PLoS ONE, 5 (2) DOI: 10.1371/journal.pone.0009158

Integrating education, research and health care in developing countries

Models on how to integrate health service and research varies from country to country. Recently Dzau and colleagues from Duke University wrote about the experiences of using academic health science to transform medicine. They write that 5 billion people living in developing countries have inadequacies in hygiene and economic development, and health-care access are the main causes of shortened life expectancies.

They write that academic health science centres (previous medical schools) should play an important role promoting health and economic development. New organizational forms might improve health service delivery. By integrating health services, education and research and making this a collective responsibility it is possible to transform medicine, improve health, and reduce health-care disparities.

In most developing countries there is a strict division between universities and public health service providers such as hospitals and community health programmes. Often the Ministries of Education own the universities and Ministries of Health own the health institutions. Thus, universities become places where students get their degrees, and the quality of training often lacks the practical and real-life touch. The little research that is done is often weak and does not influence practice or policy making.

I believe we need new organisational frameworks integrating education, service and research to solve the huge challenges facing health in developing countries. Such an organization, that could include external partnerships, need to set research priorities, and develop models of education, care delivery and community health programmes, and has potential to enable health transformation.

Dzau, V., Ackerly, D., Sutton-Wallace, P., Merson, M., Williams, R., Krishnan, K., Taber, R., & Califf, R. (2010). The role of academic health science systems in the transformation of medicine The Lancet, 375 (9718), 949-953 DOI: 10.1016/S0140-6736(09)61082-5

Important health research from Ethiopia

Although the disease burden among people in the developing world is much larger than that of the rich countries, most of health research is on health problems for the rich.

Peer-reviewed journal from countries such as Ethiopia are not widely read. However, journals such as Ethiopian Journal of Health Development contains many important studies for improving health care in the country, as shown in some examples of references below.

Tadele G. ‘Unrecognized victims’: Sexual abuse against male street children in Merkato area, Addis Ababa. Ethiop J Hlth Dev. 2009;23(3):174-82.

Ayalew Astatkie and Amsalu Feleke (2009). Utilization of insecticide treated nets in Arba Minch Town and the malarious villages of Arba Minch Zuria District, Southern Ethiopia. Ethiopian Journal of Health Development, 23 (3), 206-215

Influenza confusion

For years, scientists have warned that an influenza pandemic, similar to the 1918 Spanish flu, might cause a global catastrophe.

We will remember the 2009 H1N1 pandemic more for causing confusion than catastrophe.

Although the new H1N1 virus is dangerous for the young and for pregnant women, in otherwise healthy people it causes a disease no more severe than seasonal flu. Up till now, the new H1N1 virus eventually showed more weaknesses than strengths in the world’s ability to combat such a pandemic:

  1. The World Health Organization held lengthy debates about using the name “pandemic”.
  2. When the virus was discovered, it had been circulating in humans for months. It was thus too late to control its spread with quarantines and antiviral drugs.
  3. Regrettably, many countries began useless travel bans and quarantines.
  4. WHO used consultants from the influenza vaccine industry. Only after recommending on large-scale vaccine production, did the public learn about their conflict of interests.
  5. The predictions about the extent and timing of the epidemics were poor. And, some governments, for example in Norway, scared its population by telling them that thousands would die.

Nevertheless, the biggest wake-up call has been to develop and produce vaccines on a large-scale. Unfortunately, it came too little and too late, and was only available during the pandemic’s second wave.

Each country should now review what happened. If this pandemic might serve as a trial run for the vicious killer that may come one day, there might be some important lessons that we learned.

Obstetric fistula in Arba Minch

In Ethiopia, obstetric fistula remains one of the most visible indicators of inadequate maternal health care. Obstetric fistula still exists because health care systems fail to provide accessible, quality maternal health care, including family planning, skilled birth attendance, and basic and emergency obstetric care, and affordable treatment of fistula.

Thankfully, prevention and treatment of obstetric fistula has during the last three years gained attention in South Ethiopia. In 2005, the Yirga Alem Fistula Hospital opened. This was build with Norwegian support, and Addis Ababa Fistula Hospital runs the unit.

This week, we opened the second Fistula Unit in Arba Minch in south Ethiopia. It is a private gift. Altogether it has a new delivery (16 beds) and gynaecological (40 beds) wards, new outpatient departments for women and children, and a 24-bed fistula unit, and two new operation theatres. Through this work we hope to reduce maternal deaths and reduce obstetric fistulas.

We have agreed with the local government and peasant associations to help us in finding women with fistulas.

During the past two years, 250 women from this area were operated in Yirga Alem. Now they do not need to travel 250 km to get treatment.

Our work shall be done in close collaboration the Addis Ababa Fistula Hospital and with the Unit in Yirga Alem.

The influenza epidemic

The H1N1 influenza epidemic has received much media attention. Authorities fear a severe epidemic resembling the Spanish Flue, and they have taken their precautions. Norway has bought vaccines for the whole population, and has upgraded its hospitals to treat severe complications such as respiratory failure. The cost is uncertain, but is in the order of 1 billion Norwegian kroner (USD 160 million).

Some researchers question the government’s priorities in combating this epidemic:

Should Norway use such large funds on a mild influenza epidemic? Already in the early days of the epidemic, we got information that this was not an epidemic with high case fatality rates. The virus mainly infected young adults.

Has any estimate of the cost-effectiveness of this intervention been calculated? And, has this intervention been discussed in relation to other pressing health needs in the country? Would an intervention targeted at specific population groups be more cost-effective?

How sound is the government policy to buy 9 million doses (two doses per person) of a vaccine that is not thoroughly tested, and where the pharmaceutical industry would not cover the liabilities?

Other questions are:
How sound is the epidemiological modelling used by the Norwegian government? Should not their mathematical models have been adjusted as we learned how this epidemic evolved in other countries?

Does Norway need to strengthen its epidemiological research environment?

However, working is south Ethiopia; my most important question is how one of the richest countries in the world uses its huge wealth when meeting an irrational fear as a new swine-flue virus.
Could more lives have been saved if the rich countries used a smaller part of their influenza expenses to combat malnutrition, childhood diseases, maternal deaths tuberculosis, HIV, and malaria?

Impact factor and Tropical medicine

The latest edition of Thomson Reuter’s Journal Citation Reports has just been released. Two BioMed Central Journal rank as number 1 and number 2 in the TROPICAL MEDICINE category. The Malaria Journal is the leading journal in this category, with an impact factor of 2.91.

Increasingly many researchers from developing countries now use BMC Public Health (impact factor 2.03).

Traditionally, Tropical Medicine journals had low impact factors, with most journals having values below 1.

Since I am an associate editor of BMC Public Health, I am biased. But I find it encouraging to see that international health and tropical medicine has become more widely accessible with Open Access Journals