Qualitative research

In 1993, Catherine Pope and Nicholas Mays argued for greater use of qualitative techniques in health research. They published several good papers that helped researchers understand what qualitative research is. They suggested that researchers would benefit in using qualitative methods. Since then qualitative research methods is widely accepted in health services research.

Now they are worried the methods are not always used properly.

Please read their article in this week BMJ where they critically evaluate how far qualitative research has come. They ask some thorough questions whether researchers use qualitative research to its full potential.

Pope C, Mays N, Critical reflections on the rise of qualitative research. BMJ 2009;339:b3425

Open Malaria Warning

Recently, Torleif Markussen Lunde, PhD student at Centre for International Health and Geophysical Institute at the University of Bergen, Norway, opened a blog discussing malaria prediction.

He writes:
Open Malaria Warning (OMaWa) is a child of EMaPS (Ethiopian Malaria Prediction System), and the model will also be used in a recent project funded by ESA (European Space Agency).

All models and source code will be released under GPL >=2 license once they have been published. Information on where to get the source code will be posted once the distribution system is ready (svn and track).

His blog is at open.w.uib.no

Influenza in Norway II

The Norwegian public health authorities have adjusted their prognosis for the H1N1 epidemic in the country. More important, they now describe a worst case scenario, and avoid the pitfall of forecasting a possible epidemic.

Their earlier projections were wrong, and resembled more guesswork than science.

The government is now preparing the population for a possible worst case. This is a sound policy, and would also help the population and health care system to prepare for new epidemics in the future.

However, I still think we need to evaluate how Norway translates early warnings into policy. So far it has been a costly exercise, even for one of the richest countries in the world.

Treating children with AIDS

We are reviewing the treatment results among patients receiving antiretroviral therapy at Arba Minch Hospital.


From Ethiopia there are few results published on treatment outcome in children with HIV infection. We have therefore reviewed the survival of children 14 years or younger.

The preliminary results (se Figure) show the five-year survival rate is about 90 %.

Most of the deaths occur during the first twelve months, and usually occurs among patients with advanced disease when we started treatment.

Long-term outcome of HIV treatment

We are reviewing the outcome of antiretroviral treatment at Arba Minch Hospital. We started treating patients in 2003, and since then about 1550 patients have received the antiviral drugs.

Our early papers showed the death rates among patients were high during the first months of treatment. We thought the reasons for these high death rates were the patients came late for treatment; that is, they presented themselves with late stage disease.

Our objective for the study is to see if the treatment results improve over time, and if patients present with earlier stage disease. Dr Zewdie Mulissa and Dr Degu Dare take part in this study.

Our preliminary findings confirm improved survival, and that patients come earlier for treatment. We are now also trying to find out what happens to patients after they are diagnosed with HIV until they start treatment.

Leishmaniasis

Leishmaniasis is a disease caused by leishmania parasites. It is transmitted by the bite of sand fly. Most often the disease is transmissible from animals (zoonosis). South-west Ethiopia, has both the cutanous form and the visceral form of the disease.

The picture shows a boy with cutaneous leishmaniasis from Ochollo. Ochollo is about 35 km north of Arba Minch, and is a place were people live in close contact the hyrax, the animal that is the reservoir of the disease.

Visceral leishmaniasis is a severe form in which the parasites have migrated to the organs such as the spleen, liver and bone marrow. It is endemic in the lowlands.

Arba Minch Hospital has a research centre for leishmaniasis where they do clinical trials for new drugs for visceral leishmaniasis.

About obstetric fistulas

The vesico vaginal fistula (VVF) is as old as mankind, and has always been a source of misery of the affected women. Most communities consider these women as outcasts, because they leak urine down their legs, their clothes are wet, and the women smell.

The main case of VVF is obstructed labour which is not relieved in time by a caesarean section. The vagina and bladder walls become compressed between the foetal scull and the maternal pelvis, resulting in pressure necrosis. This results in obstetric fistula.

Obstetric fistulas have disappeared in the industrialized countries. In developing countries it is a public health problem, and 1-2 women per 1000 deliveries end in obstetric fistula.

In south-west Ethiopia we work on a programme to reduce maternal deaths and obstetric fistulas. With an estimated population of 2.6 million, and a crude birth rate of 38/1000, we have estimated that about 800 women die every year and 150 women get an obstetric fistula.

The main aim of our current work in south Ethiopia is to reduce these death and fistulas.

Obstetric fistula in Arba Minch

In Ethiopia, obstetric fistula remains one of the most visible indicators of inadequate maternal health care. Obstetric fistula still exists because health care systems fail to provide accessible, quality maternal health care, including family planning, skilled birth attendance, and basic and emergency obstetric care, and affordable treatment of fistula.

Thankfully, prevention and treatment of obstetric fistula has during the last three years gained attention in South Ethiopia. In 2005, the Yirga Alem Fistula Hospital opened. This was build with Norwegian support, and Addis Ababa Fistula Hospital runs the unit.

This week, we opened the second Fistula Unit in Arba Minch in south Ethiopia. It is a private gift. Altogether it has a new delivery (16 beds) and gynaecological (40 beds) wards, new outpatient departments for women and children, and a 24-bed fistula unit, and two new operation theatres. Through this work we hope to reduce maternal deaths and reduce obstetric fistulas.

We have agreed with the local government and peasant associations to help us in finding women with fistulas.

During the past two years, 250 women from this area were operated in Yirga Alem. Now they do not need to travel 250 km to get treatment.

Our work shall be done in close collaboration the Addis Ababa Fistula Hospital and with the Unit in Yirga Alem.

The influenza epidemic

The H1N1 influenza epidemic has received much media attention. Authorities fear a severe epidemic resembling the Spanish Flue, and they have taken their precautions. Norway has bought vaccines for the whole population, and has upgraded its hospitals to treat severe complications such as respiratory failure. The cost is uncertain, but is in the order of 1 billion Norwegian kroner (USD 160 million).

Some researchers question the government’s priorities in combating this epidemic:

Should Norway use such large funds on a mild influenza epidemic? Already in the early days of the epidemic, we got information that this was not an epidemic with high case fatality rates. The virus mainly infected young adults.

Has any estimate of the cost-effectiveness of this intervention been calculated? And, has this intervention been discussed in relation to other pressing health needs in the country? Would an intervention targeted at specific population groups be more cost-effective?

How sound is the government policy to buy 9 million doses (two doses per person) of a vaccine that is not thoroughly tested, and where the pharmaceutical industry would not cover the liabilities?

Other questions are:
How sound is the epidemiological modelling used by the Norwegian government? Should not their mathematical models have been adjusted as we learned how this epidemic evolved in other countries?

Does Norway need to strengthen its epidemiological research environment?

However, working is south Ethiopia; my most important question is how one of the richest countries in the world uses its huge wealth when meeting an irrational fear as a new swine-flue virus.
Could more lives have been saved if the rich countries used a smaller part of their influenza expenses to combat malnutrition, childhood diseases, maternal deaths tuberculosis, HIV, and malaria?